> At a Glance
> – People who quit GLP-1 injections regain 0.4 kg per month
> – All lost weight likely returns within two years
> – Regain speed nearly four times faster than after diet programs
> – Why it matters: Rising use of Ozempic and Wegovy makes long-term results critical
A sweeping analysis of 37 studies tracking 9,341 adults shows that quitting popular injections like Ozempic, Wegovy, Mounjaro and Zepbound triggers rapid weight regain, with most pounds back within 24 months.
The Regain Rate
Published in the British Medical Journal, the review found participants put back 0.4 kg (0.88 lb) each month once treatment ended. At that pace, all slimming benefits vanish faster than after standard diet-and-exercise plans.
Dr. Susan Jebb of Oxford, the study’s lead, warned:
> “People buying these need to be aware of the risk of fast weight regain when the treatment ends.”
What Happens to Health Markers
Cardiometabolic improvements-blood sugar, cholesterol, blood pressure-were projected to return to pre-treatment levels in less than 1.4 years, mirroring the weight rebound.
Data Snapshot
| Metric | During Drug | After Stopping |
|---|---|---|
| Average regain | – | 0.4 kg/month |
| Time to full regain | – | < 2 years |
| Follow-up range | 39 weeks | 32 weeks |
Key Takeaways
- Half of users abandon GLP-1 drugs within 12 months
- Weight creeps back nearly four times quicker than after lifestyle changes
- Health benefits fade alongside the pounds
- Evidence drawn from clinical trials; real-world patterns still being tracked
The findings underscore that while injections can spark dramatic loss, stopping treatment restarts the scale’s climb-often faster than patients expect.
